A legendary dog trainer believes he can transform Marmaduke from an undisciplined, but lovable dog, into the first Great Dane to win the World Dog Championship.

因偶然的事故而独自留在了宇宙中的男人（都暻秀 饰）和想要让他平安返回的地球上的另一个男人（薛景求 饰）间的殊死故事。